The Rapid Acceleration of Diagnostics (RADx)

The rapid worldwide spread and impact of COVID-19 has created a need for accurate, reliable, and readily accessible testing on a massive scale. To meet this challenge, the RADxSM initiative created programs that will make it possible to rapidly scale up testing across the country and help make tests available to the people who need them most.

RADx Advanced Technology Platforms (RADx-ATP)

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Goal:

Increase testing capacity and throughput by identifying existing and late-stage testing platforms for COVID-19 that are advanced enough to achieve rapid scale-up or expanded geographical placement in a short amount of time. 

Budget: $230 million

Summary:

Specific projects include scaling up existing technologies that already have or are near U.S. Food and Drug Administration (FDA) authorization for SARS-CoV-2 detection, establishing or expanding regional testing hubs to validate and perform clinical tests, and accelerating the development and implementation of tests for multiple infectious diseases, including viruses and the immune response, bacteria, and genetics.

RADx Radical (RADx-rad)

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Goal:

Support new, nontraditional approaches that address current gaps in COVID-19 testing, as well as applications of existing approaches to make them more usable, accessible, or accurate. These approaches may lead to new ways to identify SARS-CoV-2 as well as potential future viruses. 

Budget: $200 million

Summary:

Examples of nontraditional approaches include community wastewater analysis and other surveillance methods; novel analytical platforms, such as next-generation sequencing, coupled with point-of-care, noninvasive sample collection; screening and home-based tests; integrating artificial intelligence (AI) systems with novel biosensing or laboratory diagnostics and digital health technologies to screen, diagnose, and monitor COVID-19 and predict disease severity; and automatic, real-time detection and tracing of SARS-CoV-2 by integrating virus-sensing elements with touchscreen or other digital devices.

RADx Tech

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Goal:

Develop, validate, and commercialize point-of-care and home-based tests — and improve clinical laboratory tests — that can directly detect the virus.

Budget: $500 million

Summary:

RADx Tech has expanded the Point of Care Technology Research Network (POCTRN). Scientists and inventors with a rapid testing technology compete in a national “shark tank”–type COVID-19 testing challenge for a share of up to $500 million over all phases of development. The technologies go through a highly competitive, rapid, three-phase selection process to identify the best candidates for at-home or point-of-care tests for COVID-19. Finalists are then matched with technical, business, and manufacturing experts to increase the odds of success.

If certain selected technologies are already relatively far along in development, they can be advanced immediately to the appropriate step in the commercialization process.

RADx Underserved Populations (RADx-UP)

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Goal:

Understand why COVID-19 affects some people more severely than others and help people in the communities that are hit hardest.

Budget: $500 million

Summary:

NIH is developing community-engaged projects across the United States to assess and expand COVID-19 testing for these underserved and/or vulnerable populations, which include African Americans and American Indians/Alaska Natives; people in nursing homes, jails, rural areas, or underserved urban areas; pregnant women; and the homeless. Activities include establishing multiple clinical research sites across the country and encouraging collaboration between the program sites and the community — tribal health centers, houses of worship, homeless shelters, and prison systems — to identify and address their unique needs.

RADx Governance

Diana Bianchi, M.D.
Eunice Kennedy Shriver National Institute of Child Health and Human Development

Patti Brennan, Ph.D.
National Library of Medicine

Noni Byrnes, Ph.D.
Center for Scientific Review

Richard Hodes, M.D.
National Institute on Aging

Helene Langevin, M.D.
National Center for Complementary and Integrative Health

Eliseo Pérez-Stable, M.D.
National Institute on Minority Health and Health Disparities

Tara Schwetz, Ph.D. (Co-Chair)
NIH Office of the Director

Bruce Tromberg, Ph.D.
National Institute of Biomedical Imaging and Bioengineering

Rick Woychik, Ph.D. (Co-Chair)
National Institute of Environmental Health Sciences

David George, Ph.D.
National Institute of Biomedical Imaging and Bioengineering

Jill Heemskerk, Ph.D.
National Institute of Biomedical Imaging and Bioengineering

Tiffani Bailey Lash, Ph.D.
National Institute of Biomedical Imaging and Bioengineering

Todd Merchak
National Institute of Biomedical Imaging and Bioengineering

Bruce Tromberg, Ph.D.
National Institute of Biomedical Imaging and Bioengineering

Charles Anamelechi
Center for Information Technology

James Anderson, Ph.D.
NIH Office of the Director

Maureen Beanan, Ph.D.
National Institute of Allergy and Infectious Diseases

Gene Civillico, Ph.D.
NIH Office of the Director

Christine Cooper
National Institute of Biomedical Imaging and Bioengineering

Kate Egan
National Institute of Biomedical Imaging and Bioengineering

Robert Eisinger, Ph.D.
National Institute of Allergy and Infectious Diseases

Rachael Fleurence, Ph.D.
NIH Office of the Director

David George, Ph.D.
National Institute of Biomedical Imaging and Bioengineering

Taylor Gilliland, Ph.D.
NIH Office of the Director

Jill Heemskerk, Ph.D.
National Institute of Biomedical Imaging and Bioengineering

William Heetderks, Ph.D.
National Institute of Biomedical Imaging and Bioengineering

Tiffani Bailey Lash, Ph.D.
National Institute of Biomedical Imaging and Bioengineering

Ray MacDougall
National Institute of Biomedical Imaging and Bioengineering

Jacqueline Martinez
National Institute of Biomedical Imaging and Bioengineering

Matthew McMahon, Ph.D.
NIH Office of the Director

Todd Merchak
National Institute of Biomedical Imaging and Bioengineering

Doug Sheeley, Sc.D.
NIH Office of the Director

Ashley Storm
National Institute of Biomedical Imaging and Bioengineering

Holly Taylor
National Institute of Biomedical Imaging and Bioengineering

Bruce Tromberg, Ph.D.
National Institute of Biomedical Imaging and Bioengineering

Andrew Weitz, Ph.D.
National Institute of Biomedical Imaging and Bioengineering

Michael Wolfson, Ph.D.
National Institute of Biomedical Imaging and Bioengineering

Diana Bianchi, M.D.
Eunice Kennedy Shriver National Institute of Child Health and Human Development

Patti Brennan, Ph.D.
National Library of Medicine

Gary Gibbons, M.D.
National Heart, Lung, and Blood Institute

Joshua Gordon, M.D., Ph.D.
National Institute of Mental Health

Richard Hodes, M.D. (Co-Chair)
National Institute on Aging

Jon Lorsch, Ph.D.
National Institute of General Medical Sciences

Eliseo Pérez-Stable, M.D. (Co-Chair)
National Institute on Minority Health and Health Disparities

William Riley, Ph.D.
Office of Behavioral and Social Sciences Research, NIH Office of the Director

Tara Schwetz, Ph.D. (Co-Chair)
NIH Office of the Director

Nora Volkow, M.D.
National Institute on Drug Abuse

Judith Arroyo, Ph.D.
National Institute on Alcohol Abuse and Alcoholism

Crystal Barksdale, Ph.D.
National Institute of Mental Health

Partha Bhattacharyya, Ph.D.
National Institute on Aging

Dorothy Castille, Ph.D.
National Institute on Minority Health and Health Disparities

Alison Cernich, Ph.D.
Eunice Kennedy Shriver National Institute of Child Health and Human Development

Janine Clayton, M.D.
Office of Research on Women’s Health, NIH Office of the Director

Gwen Collman, Ph.D.
National Institute of Environmental Health Sciences

Wilson Compton, M.D.
National Institute on Drug Abuse

Josh Denny, M.D.
All of Us Research Program, NIH Office of the Director

Qi Duan, Ph.D.
National Institute of Biomedical Imaging and Bioengineering

Valerie Florance, Ph.D.
National Library of Medicine

Jessica Gill, Ph.D.
National Institute of Nursing Research

Gregory Greenwood, Ph.D.
National Institute of Mental Health

Monica Hooper, Ph.D. (Co-Chair)
National Institute on Minority Health and Health Disparities

Richard Jenkins, Ph.D.
National Institute on Drug Abuse

Dave Kaufman, Ph.D.
National Human Genome Research Institute

Jonathan King, Ph.D.
National Institute on Aging

Dmitriy Krepkiy, Ph.D.
National Institute of General Medical Sciences

Ming Lei, Ph.D. (Co-Chair)
National Institute of General Medical Sciences

Charlene Le Fauve, Ph.D.
Scientific Workforce Diversity Office, NIH Office of the Director

Anna Mazzucco, Ph.D.
NIH Office of the Director

David Murray, Ph.D.
Office of Disease Prevention, NIH Office of the Director

Anne Pariser, M.D.
National Center for Advancing Translational Sciences

Kamilah Rashid, Pharm.D.
NIH Office of the Director

Paul Sammak, Ph.D.
National Institute of General Medical Sciences

Nadra Tyus, Dr.P.H.
National Institute on Minority Health and Health Disparities

Elizabeth Walsh, Ph.D.
NIH Office of the Director

David Wilson, Ph.D.
Tribal Health Research Office, NIH Office of the Director

Deborah Young-Hyman, Ph.D.
Office of Behavioral and Social Sciences Research, NIH Office of the Director

Leonardo Angelone, Ph.D. 
National Institute on Drug Abuse

Douglas Bell, Ph.D. 
National Institute of Environmental Health Sciences

Judith Cooper, Ph.D. (Co-chair)
National Institute on Deafness and Other Communication Disorders

Changhai Cui, Ph.D.
National Institute on Alcohol Abuse and Alcoholism 

Valerie Florance, Ph.D.
National Library of Medicine

Joel Islam, Ph.D.
NIH Office of the Director and National Heart, Lung, and Blood Institute 

Bill Kapogiannis, M.D.
Eunice Kennedy Shriver National Institute of Child Health and Human Development

Elena Koustova, Ph.D., M.B.A.
National Institute on Drug Abuse

Orlando Lopez, Ph.D.
National Institute of Dental and Craniofacial Research

Sai Majji, Ph.D.
Eunice Kennedy Shriver National Institute of Child Health and Human Development

Amanda Melillo, Ph.D.
National Institute of Dental and Craniofacial Research

Patricia Powell, Ph.D. (Co-chair)
National Institute on Alcohol Abuse and Alcoholism

Susan Sullivan, Ph.D.
National Institute on Deafness and Other Communication Disorders

Danilo Tagle, Ph.D., M.S.
National Center for Advancing Translational Sciences 

Rick Woychik, Ph.D.
National Institute of Environmental Health Sciences

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